A novel plant protein interacts with eIF3 and 60S to enhance virus-activated translation reinitiation

Thank you for submitting your manuscript to the EMBO Journal. Your study has now been seen by three referees and their comments to authors are provided below. As you can see, the referees appreciate the analysis and find the identification of RISK and the characterization of its role in TAV-dependent reinitiation interesting. However, they also raise a number of different issues with the manuscript that would have to be resolved before further consideration here. In particular referee #3 raises concerns regarding the quality of some of the data including the immunofluorescense images, immunoprecipitation and pull down analysis. Also further physiological data in support of the significance of RISP for CaMV replication is needed. As you can see there are many issues that would have to be resolved, however should you be able to address the concerns raised in full then we would be willing to look at revised version. Please note that some of the issues brought up by referee #3 are listed in the general comments and these will have to be addressed. I should remind you that it is EMBO Journal policy to allow a single round of revision only and that, therefore, acceptance or rejection of the manuscript will depend on the completeness of your responses included in the next, final version of the manuscript.